Peripheral Neuropathy
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Definition
Peripheral neuropathy is damage to the nerves that connect the spinal cord to the rest of the body.
Peripheral Nerves of the Foot |
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原因
Nerve damage may be from:
- 创伤 由于:
- Some medicines, such as chemotherapy for cancer
- Lack of certain vitamins
- Exposure to toxins 和 heavy metals, such as 引领, 汞, or pesticides
- Exposure to cold or radiation
- Alcohol use disorder
Health problems that can damage these nerves are:
- 糖尿病
- Infections, such as Lyme disease 和 tuberculosis
- Kidney failure
- Autoimmune disorders, such as rheumatoid arthritis
- Acute or chronic demyelinating polyneuropathy
- 卟啉症
- Certain problems from cancerous tumors
- Hereditary syndromes, such as Charcot Marie Tooth disease
Risk Factors
Having certain health problems may raise the risk of getting peripheral neuropathy.
症状
Nerve damage may cause problems with feeling 和 movement in the arms, h和s, legs, 和 脚. Other parts of the body may also have problems. It depends on which nerves are 影响.
Problems may be mild 和 then get worse over time. They may be worse at night. A person may have:
- Numbness or lack of feeling
- 刺痛
- Pain, often a burning or sharp, or cutting feeling
- Sensitivity when touched
- Muscle spasms
- Muscle weakness
- Problems walking
- Loss of coordination or balance
诊断
The doctor will ask about symptoms 和 past health. A physical exam will be done. Blood 和 urine tests will be done to rule out other problems or possible causes.
Nerves will be tested. This can be done with:
- Electromyography (EMG)
- Nerve conduction studies (nc)
Other tests to look for possible causes may be:
- CT扫描
- 核磁共振成像扫描
- Lumbar puncture to test the fluid around your spine
- Nerve or muscle 活组织检查
治疗
治疗 depends on what is causing the neuropathy. This can ease symptoms or make them go away. Other treatment options may be:
Physical Therapy
Exercises may be given to help with flexibility. It may help make walking easier.
医学
Pain medicine is often used. Botulinum toxin A injections may also ease pain.
医学s used to treat depression 和 prevent seizures can ease some symptoms.
People with severe problems may need:
- IV immunoglobulins to suppress the immune system
- Plasma exchange of the blood to ease swelling 和 suppress the immune system
Prevention
Manage long term health problems, such as diabetes. 这可能 prevent some forms of peripheral neuropathy.
References
- Barrell K, Smith AG. Peripheral Neuropathy. Med Clin North Am. 2019 Mar;103(2):383-397.
- Peripheral neuropathy. EBSCO DynaMed website. Available at: http://www.力学.com/condition/peripheral-neuropathy.
- Peripheral neuropathy fact sheet. National Institute of Neurological Disorders 和 中风 website. Available at: http://www.研究所.国家卫生研究院.gov/disorders/patient-caregiver-education/fact-sheets/peripheral-neuropathy-fact-sheet.